Multistep Transformations of DNA Origami Domino Array via Mechanical Forces

Nanostructures that display controllable motions and functions are indispensable to build molecular nanomachines. Structural DNA nanotechnology, enabling precise design of complex static dynamic structures, can be used construct However, designing structures present multiple motion behaviors with different stimuli-responsiveness is full challenges. Herein, multistep transformations origami domino array (DODA) triggered by mechanical forces developed. The DODA consists small, modular units, which regulated the external forces. Under expanding contraction exerted trigger G-quadruplex (G4)-functionalized loop strand, units reconfigured, leading programmable among three conformations. This transformation strategy applied chiral plasmonic metamolecules, analyze K+ via fluorescence resonance energy transfer (FRET) analysis. Moreover, shows a diversified approach DNA-based nanodevices, may find potential applications in various fields.